Kostyan sorta got me into changing my sequence as a product from another thread on here. I still fail at trying to adapt when flying many different ships game after game. Before synergy change - I could pick one ship and fly that all day long to progress. Now it’s Ship A’s turn - Then Ship B - Maybe Ship C gets some action if I die etc. Very confusing for me 
First of all, the WASD keys for motion are there for a reason. They give you direct access to nearly half the keyboard (good ol’ wow days with 50 skills and macros ERRYWHERE) and, more importantly, give your single hand on the keyboard access to the Modifier keys: Alt, Ctrl and Shift. When I use those 4 motion keys, my thumb is always over the C/V keys, my index always hovers over D/E, my middle finger on W/S, ring on Q/A and pinky for Tab, Shift and Ctrl keys.
This gives me access to HALF the keyboard (all teh way to the 5/T/G/V keys) with a twitch of my hand without ever removing my middle finger off the W key.
Keys aren’t a problem for my hand, this game is a cruise for someone like me…
Memorizing what mods are where is where your brain comes in next. Placing the same (or similar) modules in the exact same Active Slots help you control yourself without thinking too much, almost making using that ship solely by instinct. Ie, placing Flares or any other Survival module on 1, class active modules on the following slots. Ie, a debuff/self-buff on 3, an AoE buff/debuff on 4 and so forth.
If they’re permanently on (Command/Engineer/Guard), just put them next to eachother. That way, you don’t have to skip a key while turning them on and you won’t press something you shouldn’t that had a long cooldown.
I can’t explain it any clearer because this is how my mind processes a game I play. I often don’t touch the keybinds at all and just adapt to them, instead. If I feel that it somehow doesn’t work for me, I go there, switch them to something I’m more comfortable with (ie, in WoW, using 6-0 keys is… a nightmare, to say the least, so I rebind them to other keys) and go from there. It’s been working perfectly for me, thus far and I don’t plan on changing any of it.